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Alexion is a global biopharmaceutical company focused on developing and delivering life-transforming therapies for patients with devastating and rare diseases. Patients with these life-threatening diseases often have no effective treatment options, and they and their families suffer with little hope. Our goal is to deliver medical breakthroughs where none currently exist. We are driven because we know people's lives depend on our work.

Alexion developed Soliris® (eculizumab) from the laboratory through commercialization for the treatment of patients with paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS), two life-threatening, ultra-rare disorders. Today, Soliris is approved in nearly 50 countries for PNH and nearly 40 countries for aHUS. Download Soliris prescribing information.

As we continue to expand our operations into additional countries, Alexion is advancing the most robust rare disease pipeline in the biotech industry, with highly innovative product candidates in multiple therapeutic areas. Alexion is establishing a premier global metabolic rare disease franchise with two potential therapies in late-stage development, Strensiq™ (asfotase alfa) for hypophosphatasia (HPP) and Kanuma™ (sebelipase alfa) for Lysosomal Acid Lipase Deficiency (LAL Deficiency, or LAL-D). Strensiq has been approved in the EU and Japan for the treatment of patients with HPP, and Kanuma has been approved in the EU for the treatment of patients with LAL-D. In addition, as the global leader in complement inhibition, we are strengthening and broadening our portfolio of complement inhibitors across diverse platforms, including evaluating potential indications for Soliris in additional severe and ultra-rare disorders.

Alexion was established in the U.S. in 1992 and became a public company in 1996 (NASDAQ: ALXN). We were added to the NASDAQ-100 Index in 2011 and to the Standard & Poor's 500 Index in 2012.

Our global headquarters and research operations are in Cheshire, Conn., and will move to New Haven, Conn. in 2015. Alexion's more than 2,800 employees serve patients in 50 countries.

AlfaGene is an innovative biotechnology company that uses its own novel proprietary cutting edge adult stem cell technology to create the only stem cell and non-transformed primary epithelial cell derived model of each segment of the entire gastrointestinal (GI) tract.

Gastrointestinal diseases affect millions of people, young and old all across the globe and cause heavy economical consequences for nations around the world. In the United States alone, GI diseases consume over $22 billion health care dollars annually with treatments that are usually not curative but just symptom relieving.  GI stem and epithelial cells are the main cellular component affected in the malignant transformation, inflammation, immune responses (e.g. autoimmune response), and disease of the GI tract, including:

• colorectal cancer (CRC)

• ulcerative colitis (UC)

• Crohn's Disease (CD)

• irritable bowel syndrome (IBS)

• short bowel syndrome

• gastroesophageal reflux disease (GERD) and Barrett’s esophagitis.

• Alissa Pharma is a new biotechnology company focusing on radioimmunotherapy with novel targeted antibodies for hematology and solid tumors.
• Alissa Pharma has a patented platform technology for the development of bispecific monoclonal antibodies combined with radioisotopes to address unmet medical needs in hematology and oncology.
• Lead Product: Ferritarg: 90Y antiferritin polyclonal antibody is ready to enter into a phase III trial. Originally developed for relapsed and refractory Hodgkin lymphoma by two well-known US institutions (Johns Hopkins in Baltimore and MD Anderson in Houston), Ferritarg has already demonstrated safety and efficacy in Phase I/II clinical trials in more than 300 patients.
• Alissa Pharma has secured the worldwide rights for Ferritarg in all radiopharmaceutical indications and the preclinical dossier is completed.
• The market potential is in excess of $100 million in US alone in this indication based on an estimated cost per patient of $60,000. The Orphan Drug Status for Ferritarg, already obtained in both Europe and the US for the Hodgkin lymphoma indication, offers a fast track regulatory pathway for approval and provides market exclusivity for 10 and 7 years in Europe and in the US, respectively, from the approval date.
• AMB8LK: 90Y antiferritin chimerized monoclonal antibody is in preclinical development for the treatment of pancreatic cancer (pancreatic cancer cells overexpress ferritin). Preclinical data indicated that AMB8LK has a very high affinity and specificity for human ferritin. AMB8LK, radiolabelled with 90Y showed 98% stability over 7 days.AMB8LK has a broad and well-protected patent estate. The product is ready to commence clinical trials. AMB8LK can also be developed in hepatic cancer and neuroblastoma.
• Alissa Pharma has an experienced management team with a proven track record of obtaining product approvalsin both Europe and the US and generating several successful exits. In addition to time, effort, and ownership, the management team has funded all of the expenses since the inception of Alissa Pharma

Allergan is a $23 billion diversified global pharmaceutical company and a leader in a new industry model - Growth Pharma.  The company is anchored by strong and sustainable brand franchises, a leading global generics business, a premier pipeline, highly efficient operations and an experienced management team creating an unrivaled foundation for long-term growth.

The Allergan Brand portfolio features six blockbuster franchises in key therapeutic categories, including

• Dermatology and Aesthetics
• CNS
• Eye Care
• Women’s Health and Urology
• GI and Cystic Fibrosis 
• Cardiovascular and Infectious Disease

Supporting these blockbuster franchises is the company’s industry-leading U.S. sales force with extraordinary marketing reach and increased relevance with primary care physicians and specialists.

Allovate Therapeutics is a specialty pharmaceutical company dedicated to simplifying allergy treatment. Allovate’s approach to allergy immunotherapy is built around the Allerdent® therapeutic platform. 

Allerdent® is formulated as an easy-to-use, customizable toothpaste that incorporates and stabilizes the immunotherapeutic agents used to treat food and respiratory allergies. It conveniently integrates immunotherapy into an allergy sufferer’s everyday brushing routine. Allerdent® makes tackling allergies as simple as brushing your teeth. 

Clinical investigations led by Allovate Therapeutics are developing this platform for the treatment of food allergies. Allerdent® offers the potential of a long-term solution for the 15 million Americans who have food allergies. 

Allergy immunotherapy is the only disease-modifying allergy treatment, demonstrated to be effective in over 100 years of clinical use. This approach changes how the body responds to allergens over time by exposing the immune system to purified allergen extracts in a controlled way over a period of time. Our approach, oral mucosal immunotherapy (OMIT), is designed to overcome the challenges of existing approaches to immunotherapy. OMIT delivers immunotherapeutic agents to the areas of the oral cavity with the greatest potential for reducing allergy symptoms and a lower likelihood of side effects.

ABOUT US: 

Alpha Bronze is a leading provider of investor relations and strategic corporate communications. We have been working with US and non-US private and public companies to build their profiles within the investment community.

Based in New York, Alpha Bronze's single core competency is:

• the development and execution of tailored, strategic investor communication programs.

Our approach is straightforward: by thoroughly and by leveraging our expertise and knowledge of the "Street", we help our clients:

• develop clear and consistent key messages,
• raise their awareness and profiles in the global investment community and,
• ulimately maximize the market value of their stock and company.

The American Heart Association is the nation’s oldest and largest voluntary organization dedicated to fighting heart disease and stroke. Founded by six cardiologists in 1924, our organization now includes more than 22.5 million volunteers and supporters. We fund innovative research, fight for stronger public health policies, and provide critical tools and information to save and improve lives. Our nationwide organization includes 156 local offices and more than 3,000 employees. We moved our national headquarters from New York to Dallas in 1975 to be more centrally located. The American Stroke Association was created as a division in 1997 to bring together the organization’s stroke-related activities.

What We Do: To improve the lives of all Americans, we provide public health education in a variety of ways. We’re the nation’s leader in CPR education training. We help people understand the importance of healthy lifestyle choices. We provide science-based treatment guidelines to healthcare professionals to help them provide quality care to their patients. We educate lawmakers, policymakers and the public as we advocate for changes to protect and improve the health of our communities.

Ampfuul's mission is to accelerate commercialization for our client's businesses in biotechnology and the life sciences by providing a suite of business development, marketing and sales services, including implementation of strategies.