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NYU Langone Medical Center is one of the nation’s premier academic medical centers. Our trifold mission to serve, teach, and discover is achieved daily through an integrated academic culture devoted to excellence in patient care, education, and research.

Located in the heart of Manhattan, with additional facilities throughout the New York City area, NYU Langone consists of four hospitals:

• Tisch Hospital, our flagship acute-care facility
• Rusk Rehabilitation, ranked as one of the top 10 rehabilitation programs in the country by U.S. News & World Report since 1989, and recently awarded a three-year accreditation from the Commission on Accreditation of Rehabilitation Facilities  (CARF)
• Hospital for Joint Diseases, a dedicated inpatient orthopaedic hospital 
• Hassenfeld Children’s Hospital, which provides comprehensive children's health services across NYU Langone

NYU Langone Medical Center is one of the nation’s premier academic medical centers. Our trifold mission to serve, teach, and discover is achieved daily through an integrated academic culture devoted to excellence in patient care, education, and research.

Located in the heart of Manhattan, with additional facilities throughout the New York City area, NYU Langone consists of four hospitals:

• Tisch Hospital, our flagship acute-care facility
• Rusk Rehabilitation, ranked as one of the top 10 rehabilitation programs in the country by U.S. News & World Report since 1989, and recently awarded a three-year accreditation from the Commission on Accreditation of Rehabilitation Facilities  (CARF)
• Hospital for Joint Diseases, a dedicated inpatient orthopaedic hospital 
• Hassenfeld Children’s Hospital, which provides comprehensive children's health services across NYU Langone

NYU Langone Medical Center is one of the nation’s premier academic medical centers. Our trifold mission to serve, teach, and discover is achieved daily through an integrated academic culture devoted to excellence in patient care, education, and research.Located in the heart of Manhattan, with additional facilities throughout the New York City area, NYU Langone consists of four hospitals:

• Tisch Hospital, our flagship acute-care facility
• Rusk Rehabilitation, ranked as one of the top 10 rehabilitation programs in the country by U.S. News & World Report since 1989, and recently awarded a three-year accreditation from the Commission on Accreditation of Rehabilitation Facilities  (CARF)
• Hospital for Joint Diseases, a dedicated inpatient orthopaedic hospital 
• Hassenfeld Children’s Hospital, which provides comprehensive children's health services across NYU Langone

The Department of Orthopaedic Surgery is responsible for providing the full range of adult orthopaedic services to patients at the Hospital for Joint Diseases at NYU Langone Medical Center.

This specialty hospital is dedicated solely to the treatment of orthopaedic and rheumatologic conditions. Members of the Hospital for Joint Diseases service follow the highest professional standards in evaluating and treating in-hospital patients, patients who seek treatment in the numerous clinics, and patients who visit the Hospital's Immediate Care Center, a unique facility that provides urgent orthopaedic care.

CARDIOVASCULAR

Dr. Mignatti's two NIH grants support the study of a novel mechanism that controls the growth of a number of cells including the cells of the blood vessels. These cells produce a protein referred to as Membrane Type 1 Matrix Metalloproteinase (MT1-MMP). MT1-MMP has the capacity of digesting structural proteins that surround the cells, an important function for new vessels to make their way into the tissues that need to be vascularized. Unlike proteins with similar functions, MT1-MMP is bound to the cell membrane, the sheath that surrounds the cell, a feature that makes it similar to other proteins - growth factor- or hormone- receptors. These proteins have the role of relaying signals from the outside to the inside of the cell when they bind their cognate growth factors or hormones. These signals regulate many cell functions, including the capacity to grow and form new vessels. MT1-MMP also binds an extracellular protein called tissue inhibitor of metalloproteinases-2 (TIMP-2). Dr. Mignatti's group discovered that MT1-MMP binding of TIMP-2 activates signals inside the cell which stimulate cell growth and movement. The current work aims to understand the mechanisms by which MT1-MMP relays signals from the outside to the inside of the cell. For this purpose the research group uses both techniques of molecular and cellular biology, and animal models engineered in the laboratory. The results of these studies can afford the development of novel drugs to control the growth of a variety of cells including those that form blood vessel.